From evidence to defensible decisions.
CertaintyGrade helps educators, researchers, and clinicians structure clinical questions, critically appraise evidence, and make transparent certainty judgments — with every conclusion linked to the supporting evidence.
Built by a physician-educator and former Cochrane Clinical Answers editor.
No account required to start
One platform. Three tools.
GRADE is the methodological engine. CertaintyGrade is the reasoning workspace built around it.
Assess
Appraise and grade evidence
Structure a PICO question, add studies, and produce a transparent GRADE certainty rating with every domain judgment linked to the supporting evidence.
Try a Free Assessment →Journal Club
Learn through structured deliberation
Run evidence-based journal clubs for your residency or research group — with assigned positions, AI-assisted worksheets, and an instructor moderator packet.
Create a Session →Learn
Build EBM competency
Free interactive GRADE tutorial covering all five certainty domains, upgrade and downgrade factors, and the PICO question structure that anchors every assessment.
Start the Tutorial →The GRADE principle CertaintyGrade enforces
"A paper doesn't have a GRADE rating.
An answer to a specific clinical question does."
The same RCT earns different certainty levels for different questions — because directness, imprecision relative to the decision threshold, and applicability all shift with the question. GRADE is question-anchored by design. CertaintyGrade enforces that discipline.
How GRADE assessment works
Define your PICO question
Population · Intervention · Comparison · Outcome. GRADE certainty has no meaning without a clearly specified question and outcome.
Add your studies
Paste an abstract, enter a PubMed ID, or paste full text. Multiple studies produce a body-of-evidence rating.
Review before running
You confirm the question and study list before the assessment runs. The certainty rating applies to exactly what you specified.
Get a transparent, editable GRADE rating
High / Moderate / Low / Very Low certainty, with domain-by-domain rationale citing specific data points. Every judgment is reviewable.
For Educators & Residency Programs
Run structured journal clubs — not just discussions
CertaintyGrade Journal Club assigns participants to supporting or refuting positions, guides them through an evidence-based worksheet with PubMed integration, and generates an AI-assisted Moderator Packet summarizing agreement, disagreement, and teaching points.
Built on 13 years of Cochrane methodology
CertaintyGrade was built by Adarsh K. Gupta, DO, MS, FACOFP — Associate Editor at Cochrane Clinical Answers since 2012, founding director of a Center for Information Mastery, and clinical AI consultant. The methodology is pilot-benchmarked against published Cochrane GRADE ratings.
CertaintyGrade is an independent product and is not affiliated with or endorsed by the GRADE Working Group or Cochrane.
Start with a free assessment
No account required. Try the full GRADE workflow on any clinical question.